Vitamin D and immune cells stimulate bone marrow disease
Stimulation of bone marrow disease through excessive signs of vitamin D and immune cells known as macrophages, and reveals a Japanese research team. These results can help in the development of alternative therapies are not addressed problem genes. researcher team Kanako and Akahashi Associate Professor and aimed at young people, Yoshio Katayama (School of Medicine, University of Kobe), and the results were published on February 4 in the edition of the blood through the Internet.
There are three types of blood cells: white blood cells, red blood cells and platelets. All of them are created three types of hematopoietic found in stem cells of bone marrow. Causing abnormal fibroon increase in cells that produce collagen fibers called fibroblasts. The bone marrow is filled with these fibers, which vexgen keto prevents the body from naturally producing blood cells. This situation can make it difficult to control other diseases, and hardening of the bone (osteosclerosis) also occurs. Alveloveloz disease occurs in blood tumors called promyelocytic tumors, which are caused by genetic mutations of hematopoietic stem cells.
The research team focused on the relationship between blood and bones. Vitamin D is a hormone that regulates calcium, the team has already shown that the vitamin D receptor controls blood-forming cells at the site of the bone marrow. In this study, the team conducts a process of bone marrow transplantation (with vitamin D receptor) mouse model without vitamin D receptor (which means that it contains a high concentration of vitamin D in the body) to find a model for the loss of Almayoveroveros. By analyzing this model, they found that hematopoietic stem cells stimulated strongly through vitamin D signals and grown to an immune system called macrophage cells. This stimulated pathological osteoblast macrophages (cells that create bone) to stimulate bone narrowing and hardening of bones. It is believed that fibroblasts are known as bone osteoblasts. By giving these mice a diet low in vitamin D and suppressing macrophages, the team was able to prevent the appearance of Almiloveros.